About 1 result found for searched term "AMG8379 " (0.405 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28760 | AMG8379 | Sodium Channel |
| AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM. | ||
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